With the unlimited proliferative capacity and extensive differentiation potential, human pluripotent stem cells (hPSCs) present distinct advantages than adult stem cells. In order to avoid the ethical issues, the application of human embryonic stem cell (hES cells) is replaced by human induced pluripotent stem cells (hiPSCs). which can be generated from various adult somatic cell types via the introduction of four specific transcription factors: OCT3/4, SOX2, KLF4, and c-MYC. However, these hiPSCs cannot be used directly into patients because of the tumorigenic potential. In this case, a differentiation protocol is an essential prerequisite to direct hiPSCs into specific cell types. As such, the neural differentiation of hiPSCs enables a promising cell source for both regenerative medicine and cell therapy. Learn more: neural stem cells.
MUC16, well known as CA125 (carbohydrate antigen 125 or cancer antigen 125), is a member of the mucin family glycoprotein ranked as the largest membrane-associated mucin with about 22,000 amino acids, which is initially detected by the murine monoclonal antibody designated OC125 (the 125th Ab produced against the ovarian cancer cell line) and named " cancer antigen 125". It consists of a cytoplasmic tail for the interaction with cytoskeleton, a transmembrane domain and several extracellular domains including a highly O-glycosylated N-terminal domain, a tandem repeat (high in serine, threonine and proline) and multiple SEA (sea urchin sperm protein, enterokinase and agrin) modules, which contain a proteolytic cleavage site for release of extracellular region from the cell surface. Learn more: anti-MUC16 CAR-T in vivo assay.
Product Name: Bee Venom Extract From V.vulgaris & V. germanica Mixture Product Description: This venom extract is a mix of Vespula vulgaris and Vespula germanica. Vespula vulgaris and Vespula germanica both belong to the Vespidae family and the Hymenoptera order. The product can be used for applications such as a diagnostic marker, investigate the development of venom allergy, and develop a therapy against venom allergy. This product is for research use only.
As forward-looking research as well as a leading custom service provider in the field of drug discovery, Creative Biolabs is always pleased to use our extensive experience and advanced platform to offer one-stop anti-monkeypox drug discovery solutions to satisfy each demand from our customers.
As the leading custom service provider, Creative Biolabs has been keeping a close eye on the development of the epidemic situation and accelerating the development of detection kits. Creative Biolabs provides Monkeypox virus nucleic acid detection kits and ELISA kits.
Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. As the leading custom service provider specializing in antibody production and engineering fields, Creative Biolabs has been keeping a close eye on the development of the epidemic situation and accelerating the development of monkeypox antibodies.
With years of experience, Creative Biolabs can offer an extensive range of recombinant proteins and peptides including orthopoxviruses family, parapoxviruses family, molluscipoxviruses family, yatapoxviruses family, capripoxviruses family, suipoxviruses family, leporipoxviruses family and avipoxviruses family. Creative Biolabs is committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Creative Biolabs has organized a staff of outstanding scientists who have engaged in the research of macrophage reprogramming for many years. Our seasoned scientists have developed several efficient strategies for macrophage reprogramming, including Reprogramming Macrophages Employing Gene Regulatory Networks, Reprogramming Macrophages By Nanoparticles, and Reprogramming Macrophages by microRNA.
As a leading service provider in the field of antibody discovery and immunotherapy development, Creative Biolabs now presents one-stop development services for CAR-T therapy, which has become a more promising approach among cancer therapies. We offer macrophage polarization assay used to improve the antitumor immunity via promoting inflammation during the one-stop service for further downstream research.
Lipid nanoparticles (LNPs) are novel spherical vesicles with core-shell nanostructure. A typical LNP usually has a specially designed ionizable lipid component, which is positively charged at low pH (for RNA complexation) and neutral at physiological pH (reducing potential toxic effects compared with cationic liposomes). Due to their special characteristics and small size (~100 nm), LNPs could be uptake by cells via endocytosis and then release the cargo into the cytoplasm by low pH mediated endosomal escape. Thus, the LNPs possess additional advantages over the traditional lipid-based carriers such as improved nucleic acid encapsulation and transfection efficiency, better penetration capacity, and decreased cytotoxicity.