Single-cell sequencing technologies such as 10X Genomics, BD Phrapsody, and Illumina Hiseq have emerged that allow us to profile the genome, transcriptome and epigenomics of individual cells, unravel the heterogeneity of cell genotype, phenotype, and function within a complex cell population. Currently, single-cell sequencing technologies have been applied in a wide of life science research, including in oncology, developmental biology, microbiology, neuroscience, botany, and other fields. As an expert in the field of single-cell sequencing and analysis, Creative Biolabs provides the best and most comprehensive single-cell sequencing and analysis services. Learn more: Single Cell DNA-seq

Creative Biolabs is a leading service provider that focuses on ribosomal proteomics research. Based on our advanced platforms and extensive experience, now we can provide the ribosomal protein expression service based on various expression systems.

Given that it affects the rest of the world in addition to countries in west and central Africa, monkeypox is a disease of worldwide public health significance. Close contact with respiratory secretions, skin sores on an infected person, or recently contaminated objects can cause human-to-human transmission. Health professionals, family members, and other close contacts of current patients are more at risk because droplet respiratory particles typically require extended face-to-face contact. Learn more: monkeypox test

γδ T cells are a population of innate-like T lymphocytes characterized by T-cell receptors (TCRs) composed of γ and δ chains. They are widely distributed in the peripheral blood (PB) and mucosal tissues. γδ T cells have been revealed to exert dual roles in tumor immunity. On the one hand, γδ T cells suppress tumor occurrence by multiple mechanisms, including cytotoxicity against infected or tumor cells, cytokine and chemokine production, antigen-presenting functions, and regulatory abilities. On the other hand, γδ T cells exert suppressive effects on antitumor responses. Learn more: gamma delta T cell markers

Electrophysiology techniques provide a wealth of information regarding the molecular mechanisms that underlie the function and modulation of ion channels. Creative Biolabs is a contract research organization with over 10 years of expertise in our area of neurological electrophysiology expertise. We combine expertise, world-class facilities, and cutting-edge instrumentation to support companies involved in the research and development of products for neurological diseases. Learn more: electrophysiology of neurons

Recombinant monoclonal antibody to PDCD1. Camrelizumab is a human monoclonal antibody that can be potentially used in the treatment of Breast Cancer, Lung Cancer.

Glycolipids are the carbohydrate-attached lipids which provide energy and also serve as markers for cellular recognition. They might become a new type of promising non-viral gene delivery systems because of their low cytotoxicity, structural diversity, controllable aqua- and lipo-solubility, appropriate density and distribution of positive charges, high transfer efficiency and potential targeting function. Learn more: glycoprotein and glycolipid

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-Ad fiber knob antibody variable domain are respectively connected to the N terminus of the anti-CEA IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. Learn more: Ad fiber knob CEA scFv IgG

Creative Biolabs combines deep, industry-leading expertise with an innovative Macrophage Therapeutics Development Platform to provide high-quality human/murine macrophage isolation and culture services. These isolated macrophages can be examined in vitro for their roles in phagocytosis, cytokine and mediator production, and other biological functions. Learn more: macrophage culture

Many factors should be considered when the immunogen is designed, such as length, molecular weight, secondary structure, purity, hydrophobicity, amino acids. Based on the following four major criteria, Creative Biolabs provides a full range of Immunogen Design services for hybridoma development.

As one of the most competitive biotechnology companies in the world, Creative Biolabs has extensive expertise and experience in the drug delivery field. We are committed to providing custom liposomes-based drug delivery services with state-of-the-art platforms. Meanwhile, on the basis of timely communication and reporting, our staff will ensure high-efficiency service to meet the strict project schedule. Learn more: creative delivery services

The development of intestinal microflora and its effects on gastrointestinal health have been the focus of research in recent years. As a biotechnology company keeping pace with times, Creative Biolabs has invested numerous energy and efforts in the development of probiotics-based drug discovery. Learn more: bacteria christensenella

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Learn more: f2 antibody

Empowered by state-of-the-art technologies and advanced platforms in the field of antibody discovery and immunotherapy, Creative Biolabs offers world-leading chimeric antigen receptor macrophage (CAR-MA) services for solid tumor treatment with academic purposes. Learn more: chimeric antigen receptor macrophages

Composed of ribosomal RNA molecules and proteins, ribosomes are important tools for protein synthesis in cells. ribosome complex profiling provides information on all ribosomes active in the cell at a specific time point and helps determine which proteins are actively translated in the cell. In life activities, mRNA translation is a key link that represents the flow of genetic information as well as defines the proteome.

Cardiovascular disease (CVD) is a general term for conditions affecting the heart or blood vessels. It's usually associated with a build-up of fatty deposits inside the arteries, known as atherosclerosis, and an increased risk of blood clots. It can also be associated with damage to arteries in organs such as the brain, heart, kidneys, and eyes. The risk factors for CVD include high blood pressure, smoking, diabetes mellitus, lack of exercise, obesity, among others. It is one of the main causes of death and disability but it can often largely be prevented with a healthy lifestyle. Learn more: cardiovascular diagnostic development

First demonstrated by Shinya Yamanaka's lab in 2006, the induced pluripotent stem cells (iPSCs) can be generated from different adult somatic cell types by the introduction of four transcription factors (OCT4, SOX2, KLF4, and MYC). With the pluripotency similar to embryonic stem cells (ESCs), iPSCs have shown great potential in drug discovery, disease modeling, and regenerative medicine research. Read Full Article: qPCR Analysis for Pluripotency Markers for iPSC

With the approval of two CAR-T cell therapies in 2017, the CAR-T cell treatment has been a promising tool for the treatment of advanced hematologic malignancies. However, although a lot of CAR-T cell therapies are under preclinical evaluation, this approach has not been proved to be as successful in solid tumors. One of the limitations in solid tumors lies in the poor penetration of T cells into tumors. To address this need, talented scientists from Creative Biolabs turn to genetically engineered CAR-MA, also termed MOTO-CAR, aiming to improve the ability of CAR cells to attack solid tumors. Learn more: CAR-macrophage

At Creative Biolabs, we are well-aware of the challenges of biopharmaceuticals development and the opportunities for non-IgG therapeutic antibodies development. Our rich experience and expertise in pharmacokinetics/pharmacodynamics (PK/PD) evaluation and customized solutions will help you get the useful information you need about your therapeutic antibody. With the advent of novel technologies, considerable advances have been made at Creative Biolabs in terms of PK/PD evaluation. Learn more: IgE antibodies PK/PD Evaluation

Reporter phage assays are very sensitive as they only detect active and viable cells. Another advantage is that the robustness of the assay and the high specificity of the phage, eliminating the need for lengthy sample preparation or purification. There is a large body of literature focusing on the construction and evaluation of many different reporter phages, such as luciferase reporter phage (LRP), green fluorescent protein (GFP) reporter phage, LacZ reporter phage, Ice nucleation (inaW) reporter phage, CelB reporter phage, etc.

Alzheimer's disease (AD) presently occupies the topmost position among the most diagnosed neurodegenerative diseases worldwide, with the number of affected people forecasted to reach 100 million by 2050. According to the latest statistics, nearly 44 million people in the world suffer from AD or related dementia, with only one in four being diagnosed with the disease. Currently, the disease has no cure available for its treatment, except for some relief from some of the symptoms. Besides its multifactorial and heterogeneous nature, AD is also progressive, i.e., the symptoms gradually worsen with the passage of years. Multiple risk factors including genetic and environmental sources have been implicated in the emergence of AD, with advancing age being identified as the most significant among them. Learn more: Alzheimer's Disease Cell Models

Creative Biolabs offers a wide range of cutting-edge research products geared toward the investigation of biological processes underlying Alzheimer's disease. Our products including antibodies, cell lines, proteins & peptides, and assay kits, are among the bio-reagents keenly sought by neuroscience researchers. Learn more: Positive Regulation of Cell Migration

Recombinant Anti-Ad fiber knob x Anti-CEA Bispecific Antibody (IgG(L)-scFv) is formed by an IgG and two scFv moieties. The scFv fragments from an anti-Ad fiber knob antibody are fused to the C terminus of an anti-CEA IgG light (L) chains, or vice versa. It is a type of appended IgGs, which is bispecific and tetravalent (2+2 antigen-binding valency). This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing. Learn more: Ad fiber knob CEA IgG(L) scFv

Recently, the rapid spread of 2019 novel coronavirus (SARS-CoV-2) has become a global public health issue. As a result, many attempts have been made in disease therapy and population control, but SARS-CoV-2 surveillance still needs to be improved. Real-time reverse transcription polymerase chain reaction (rRT-PCR) has been regarded as the gold standard for in vitro diagnostic of SARS-CoV-2 in human samples. However, this system also presents many limitations, such as high manpower and equipment resources, to detect the SARS-CoV-2 genome. In this condition, the establishment of effective viral screening systems should be beneficial to the rapid diagnostic capacity of SARS-CoV-2 in potential patients. Learn more: RT-LAMP for SARS-CoV-2

The monkeypox virus pcr kit is a real-time PCR technique for detecting MPXV DNA in a liquid sample. The J2R gene, which is specific to the MPXV genome, is located using a fluorescent probe and specific primer sets. This product is furnished for research use only. Not for diagnostic or therapeutic use.

As a world-leading service provider of antibody development and engineering, Creative Biolabs has combined artificial intelligence, big data, and machine learning to generate a novel artificial intelligence (AI)-powered computational antibody drug discovery platform to predict antibody-antigen binding and provide antibody drug candidates. This platform has been considered as an attractive strategy for producing human antibodies with high specificity and affinity. Learn more: AI technologies Platform

In the recent years, more and more attention has been paid to investigate the roles of exosomes in therapeutic and diagnostic applications. Exosome labeling is a novel strategy for monitoring exosomes trafficking in vivo, which contributes to optimizing exosome-based diagnosis and treatment. With years of experiences in exosome labeling, Creative Biolabs has developed fluorescent labeling and biotin labeling techniques to track the distribution and movement of the specific exosomes.

The technology of induced pluripotent stem cell (iPSC) lines generation provides a valuable resource for disease modeling, regenerative therapy, and development study. However, the accumulation of karyotypic during long-term iPSCs culture results in chromosomal abnormalities, changes in gene expression and cellular functions, and even increases the risk of the iPSCs being tumorigenic. As genomic alterations present potential risks in the iPSCs applications, it is important to monitor the genomic integrity of these iPSCs lines especially in iPSCs intended for therapeutic use. Now Creative Biolabs has developed various strategies for the iPSC karyotype analysis. iPSC karyotype analysis is the examination of morphology. Moreover, the changes in size, the position of centromeres, and banding patterns are also necessary for detection aspects. Learn more: stem cell karyotype

Anti-glycan antibodies are essential for basic research. Here, Creative Biolabs gives an introduction to the application of anti-glycan antibodies in glycan identification so as to detect and monitor the expression of specific carbohydrate determinants on cell-surface or in other biological samples. Learn more: Anti-Glycan Antibody in Glycan Identification

In response to the current monkeypox outbreak, as a leading company in biotechnology, Creative Biolabs provides one-stop virus-like particle (VLP) vaccine-based anti-monkeypox drug discovery solutions for our clients. Our services are not limited to the screening of viral surface antigen modules, the production and assembly of VLPs, and the evaluation of the anti-monkeypox efficacy of VLP vaccines. Our cutting-edge technology platform will provide the most comprehensive services with stable and high-quality results. Learn more: virus-like particle vaccine

Equipped with state-of-the-art artificial intelligence, big data, and machine learning, Creative Biolabs offers a wide variety of antibody engineering services to quickly and efficiently optimize the existing antibodies via artificial intelligence (AI) based algorithms, such as affinity, solubility, cross-reactivity, manufacturability, immunogenicity, specificity, stability. Learn more: machine learning antibody engineering

Xenograft models are integral in the process of anti-tumor drug discovery and provide critical decision-making information to ensure the advancement of a novel agent. Cooperating with Creative Biolabs provides you with the access to validated and well-characterized xenograft models. Our highly experienced preclinical team are ready to assist you establishing the most appropriate xenograft tumor model and screening method for your research on anti-tumor drug discovery. Learn more: mice xenograft tumor model

Recombinant monoclonal antibody to folate receptor 1. Farletuzumab (MORAb-003) is a monoclonal antibody which is being investigated for the treatment of ovarian cancer, It is targeted at FR-alpha which is overexpressed in some cancers such as ovarian cancer.

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Learn more: cxcl11 antibody

With years of research and development, Creative Biolabs has extensive experience in phage display platform by employing various types of phage in various project objectives. In general, filamentous bacteriophages (e.g. M13) are the most popular vehicle choice for phage display and extensively used in many types of research. Meanwhile, Creative Biolabs is also an expert to provide phage display related services via either T4 or T7 phage systems, which can provide different promising alternatives by their special merits.

Based on their different origins and functions, B cells can be divided into two types: B-1 cells and B-2 cells. B-2 cells are classical B lymphocytes that mainly exist in peripheral blood and lymphoid organs, accounting for approximately 45% of peripheral blood B lymphocytes. After first encountering an antigen, B-2 cells undergo clonal expansion and, with the help of T cells, produce high-affinity IgM antibodies. Learn more: B-2 Cells that Produce IgM Antibodies

Derived from early blastocyst embryos, human embryonic stem cells (hESC) are self-renewable cells with pluripotency. Under special culture conditions, neural cells can be generated from hESC including glial cells, functional neurons, and oligodendrocytes. To avoid other lineage cells as contaminants, the neural progenitor (NP) cell population is necessary to the neural lineage and has been served as an unlimited lineage-restricted cell source for therapeutic and research. Learn more: ipsc to neurons

Recombinant monoclonal antibody to BAFF. Tabalumab (LY 2127399) is an anti-B-cell activating factor (BAFF) human monoclonal antibody designed for the treatment of autoimmune diseases and B cell malignancies.

CD79B (CD79b Molecule) is a Protein Coding gene. Diseases associated with CD79B include Agammaglobulinemia 6, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. Learn more: cd79b marker.

At Creative Biolabs, total complement activity tests are respectively carried out by CH50 for the complement classical pathway, AH50 for the complement alternative pathway, and LP50 for the complement lectin pathway. Among the tests, CH50 and AH50 assays are based on the complement hemolytic activity detection while the LP50 is based on the enzyme immunoassay of the terminal complement complex detection. All test procedures are shown as follows, both a one-stop test for all three pathways and a test for any one pathway based on the client’s demands are all available. Learn more: hemolytic assay complement

Creative Biolabs has always been interested in the development of a novel drug delivery system, which aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and channel the active entity to the site of action. In recent years, vesicles have become the vehicle of choice in drug delivery. Having worked in the field of bioactives delivery for many years, Creative Biolabs has developed comprehensive sets of innovative and diversified drug delivery platforms based on vesicular system. At present, we are able to provide a full range of services and customized products concerning versatile carrier. Learn more: Vesicular system-based drug delivery.

With the unlimited proliferative capacity and extensive differentiation potential, human pluripotent stem cells (hPSCs) present distinct advantages than adult stem cells. In order to avoid the ethical issues, the application of human embryonic stem cell (hES cells) is replaced by human induced pluripotent stem cells (hiPSCs). which can be generated from various adult somatic cell types via the introduction of four specific transcription factors: OCT3/4, SOX2, KLF4, and c-MYC. However, these hiPSCs cannot be used directly into patients because of the tumorigenic potential. In this case, a differentiation protocol is an essential prerequisite to direct hiPSCs into specific cell types. As such, the neural differentiation of hiPSCs enables a promising cell source for both regenerative medicine and cell therapy. Learn more: neural stem cells.

MUC16, well known as CA125 (carbohydrate antigen 125 or cancer antigen 125), is a member of the mucin family glycoprotein ranked as the largest membrane-associated mucin with about 22,000 amino acids, which is initially detected by the murine monoclonal antibody designated OC125 (the 125th Ab produced against the ovarian cancer cell line) and named " cancer antigen 125". It consists of a cytoplasmic tail for the interaction with cytoskeleton, a transmembrane domain and several extracellular domains including a highly O-glycosylated N-terminal domain, a tandem repeat (high in serine, threonine and proline) and multiple SEA (sea urchin sperm protein, enterokinase and agrin) modules, which contain a proteolytic cleavage site for release of extracellular region from the cell surface. Learn more: anti-MUC16 CAR-T in vivo assay.

Introduction of Fatty Acids (FAs) are carboxylic acids with a long aliphatic chain, either saturated or unsaturated. FA vesicles are colloidal suspensions of closed lipid bilayers, which are composed of fatty acids and their ionized species (soap). They are observed in a small region within the fatty acid-soap-water ternary phase diagram above the chain melting temperature (Tm) of the corresponding fatty acid-soap mixture.

Formulation Stability Monitoring Service at Creative Biolabs: Integrated with other advanced platforms, Creative Biolabs provides the most comprehensive products and services including liposome stability analysis. Physical, chemical and microbiological parameters must be considered and evaluated when designing stability studies.

Introduction to iPSC Research Methods: The iPSC technology is undoubtedly the most outstanding achievement made by the Stem Cell Research Institute, so it was selected as the top scientific and technological breakthrough in 2009. Unlike classic embryonic stem cell technology and somatic cell nuclear transfer technology, iPSC technology does not use embryonic cells or egg cells, avoiding ethical disputes. Moreover, the patient can use iPSC derived from autologous cells, thus avoiding immune rejection. In all, iPSC technology is greatly promising for clinical cell therapy.

mesenchymal stem cell research: Mesenchymal stem cells (MSC) have received significant attention in recent years with regard to their suitability for use in cellular therapies due to their high growth potential and multipotential differentiation capacity. As a trusted research partner in the field of biotherapeutics, Creative Biolabs provides cutting-edge cell therapy research services covering every stage of MSC development, including isolation, expansion, characterization, and differentiation.

It is worth noticing that the fluorophore molecules conjugated to a given antibody should be similar in primary and isotype control antibodies. However, these fluorophore could be varied because of different manufacturers. Therefore, it is recommended to purchase both primary antibody and isotype control from the same supplier as far as possible.

Our antibody engineering team provides independent, custom service packages including antibody reformatting and production, epitope binning and mapping, antibody humanization, affinity maturation, affinity measurement, sequence liability identification, immunogenicity prediction, therapeutic developability assessment, and many other antibody specialization and modification services.

Anti-SARS-CoV antibodies: Severe acute respiratory syndrome (SARS), caused by SARS coronavirus (SARS-CoV), is a kind of respiratory viral diseases. It was first reported in 2003. Currently, there is no reported SARS transmission in the world. However, another kind of coronavirus, SARS-CoV-2 caused COVID-19 has become a pandemic since last December, 2019. COVID-19 showed many similarities to the previous SARS outbreak. Now worldwide scientists are dedicated to exploring mechanisms of SARS-CoV-2 and developing novel therapies to control this pandemic.

Anti-Rotavirus Antibodies: Outer capsid proteins VP4 and VP7, inner capsid VP6 and core VP2 are widely studied targets. Among them, the most frequent human B cell response is directed to the internal protein VP6. Protective and neutralizing antibodies induced in animals or humans following a rotavirus infection classically are thought to be directed against VP4 and VP7. At present, Creative Biolabs offers ready-to-use catalogue and mAb development services in various species with guaranteed success based on standard endpoints or customer's specific applications.